Material Safety Data
Oxalic acid, dihydrate, reagent ACS
MSDS Name: Oxalic acid, dihydrate, reagent ACS
Section 1 - Chemical Product and Company
Numbers: AC423150000, AC423150010, AC423150050
Ethanedioic acid dihydrate.
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America,
For emergencies in the US, call CHEMTREC:
Section 2 -
Composition, Information on Ingredients
||Oxalic acid, anhydrous
||Oxalic acid dihydrate
Hazard Symbols: XN
Section 3 - Hazards
Appearance: white. Danger! May cause severe respiratory
tract irritation with possible burns. May cause severe digestive tract
irritation with possible burns. May cause kidney damage. May cause eye and skin
irritation with possible burns. Harmful in contact with skin and if swallowed.
Target Organs: Kidneys, heart, eyes, skin, brain, nerves,
Eye: May cause severe eye irritation.
May result in corneal injury.
Skin: Causes skin irritation.
Harmful if absorbed through the skin. Rare chemical burns may occur from oxalic
acid and may cause hypocalcemia. Gangrene has occurred in the hands of people
working with oxalic acid solutions without rubber gloves. The skin lesions are
characterized by cracking of the skin and the development of slow-healing
ulcers. The skin may be bluish in color, and the nails brittle and yellow.
Ingestion: Oxalic acid is toxic because of its acidic and
chelating properties. It is especially toxic when ingested. As little as 5 grams
(71 mg/kg) may be fatal. Ulcerations of the mouth, vomiting of blood, and rapid
appearance of shock, convulsions, twitching, tetany, and cardiovascular collapse
may occur following ingestion of oxalic acid or its soluble salts. Oxalic acid
can bind calcium to form calcium oxalate which is insoluble at physiological pH.
Calcium oxalate thus formed might precipitate in the kidney tubules and the
brain. Hypocalcemia secondary to calcium oxalate formation might disturb the
function of the heart and nerves.
Inhalation: Inhalation of
oxalic acid produces irritation of the respiratory tract, ulceration of the
mucous membranes, headaches, nervousness, cough, vomiting, emaciation, back pain
(due to kidney injury), and weakness.
of oxalic acid dust or mist over a long period of time might result in weight
loss and respiratory tract inflammation. Rats administered oxalic acid at 2.5
and 5% in the diet for 70 days developed depressed thyroid function and weight
loss. A study of railroad car cleaners in Norway who were heavily exposed to
oxalic acid solutions and vapors revealed a 53% prevalence of urolithiasis (the
formation of urinary stones), compared to a rate of 12% among unexposed workers
from the same company.
Section 4 - First Aid
Eyes: In case of contact, immediately flush eyes
with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin: In case of contact, immediately flush skin with
plenty of water for at least 15 minutes while removing contaminated clothing and
shoes. Get medical aid immediately. Wash clothing before reuse.
Ingestion: If swallowed, do NOT induce vomiting. Get
medical aid immediately. If victim is fully conscious, give a cupful of water.
Never give anything by mouth to an unconscious person.
Inhalation: If inhaled, remove to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid.
Notes to Physician: Treat symptomatically
Antidote: Intravenous administration of
calcium gluconate or calcium chloride may be required if hypocalcemia or
hypocalcemic tetany occur.
Section 5 - Fire
Information: As in any fire, wear a self-contained breathing apparatus
in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective
gear. During a fire, irritating and highly toxic gases may be generated by
thermal decomposition or combustion. Use water spray to keep fire-exposed
Extinguishing Media: Use water spray, dry
chemical, carbon dioxide, or alcohol-resistant foam.
Section 6 -
Accidental Release Measures
Information: Use proper personal protective equipment as indicated in
Spills/Leaks: Vacuum or sweep up material and
place into a suitable disposal container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately, observing
precautions in the Protective Equipment section. Avoid generating dusty
conditions. Provide ventilation.
Section 7 - Handling
Handling: Wash thoroughly after handling. Minimize
dust generation and accumulation. Do not get in eyes, on skin, or on clothing.
Do not ingest or inhale. Discard contaminated shoes. Use only with adequate
Storage: Keep container closed when not in
use. Store in a cool, dry, well-ventilated area away from incompatible
Section 8 - Exposure
Controls, Personal Protection
Controls: Facilities storing or utilizing this material should be
equipped with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the permissible
|Oxalic acid, anhydrous
||1 mg/m3 TWA; 2 mg/m3 STEL
||1 mg/m3 TWA 500 mg/m3 IDLH
||1 mg/m3 TWA|
|Oxalic acid dihydrate
OSHA Vacated PELs: Oxalic
acid, anhydrous: 1 mg/m3 TWA; 2 mg/m3 STEL Oxalic acid dihydrate: No OSHA
Vacated PELs are listed for this chemical.
Eyes: Wear appropriate protective
eyeglasses or chemical safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin
Clothing: Wear appropriate protective clothing to
prevent skin exposure.
Respirators: Follow the OSHA respirator
regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a
NIOSH or European Standard EN 149 approved respirator when necessary.
Section 9 - Physical
and Chemical Properties
Vapor Pressure: .92 mm Hg @ 60 deg C
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not applicable.
Freezing/Melting Point:104 deg C sublimes
Temperature: Not applicable.
Flash Point: Not applicable.
Decomposition Temperature:Not available.
(estimated) Health: 3; Flammability: 1; Reactivity: 0
Upper: Not available.
Section 10 -
Stability and Reactivity
Stability: Stable under normal temperatures and pressures.
to Avoid: Dust generation, metals.
Incompatibilities with Other
Materials: Strong oxidizing agents, hypochlorite, silver, strong alkalies,
chlorites, furfuryl alcohol.
Hazardous Decomposition Products: Carbon
monoxide, carbon dioxide, acrid smoke and fumes, formic acid.
Polymerization: Has not been reported.
Section 11 -
CAS# 144-62-7: RO2450000
CAS# 6153-56-6 unlisted.
Draize test, rabbit, eye: 250 ug/24H
Draize test, rabbit, skin: 500 mg/24H Mild;
Oral, rat: LD50 = 7500
144-62-7: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. CAS# 6153-56-6: Not
listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Teratogenicity: No information found.
Reproductive Effects: Oxalic acid caused kidney damage in fetal sheep
and rats and disturbed the estrus cycle in rats. Increased sperm abnormalities
were seen in the second generation of mice administered 0.2% oxalic acid in the
Neurotoxicity: No information available.
Mutagenicity: No information available.
Standard Draize Test: Administration onto the skin (rabbit) = 500 mg (Mild).
Standard Draize test Administration into t he eye:250 ug/24H (Severe).
Section 12 -
Fish: Bluegill/Sunfish: LC50 = 4000 mg/L; 24 Hr.; Static Conditions Mosquito
Fish: LC50 = 1350 mg/L; 24 Hr.; Static Conditions No data available.
Environmental: An estimated Koc value of 5 for oxalic acid indicates
high mobility in soil and oxalic acid has been detected in groundwater. Several
screening studies and grab sample tests indicate that under aerobic and
anaerobic conditions, oxalic acid will readily biodegrade in aquatic ecosystems.
Based on an experimental Henry's Law constant of 1.4X10-10 atm-m3/mole at 25°C,
oxalic acid is expected to be essentially nonvolatile from water. Adsorption to
sediment and bioconcentration in aquatic organisms may not be important fate
process for oxalic acid.
Physical: Oxalic acid in the ambient
atmosphere may react slowly with OH radicals, but it is removed rapidly by
photolysis; the daytime persistence of oxalic acid is not expected to exceed a
few hours. Based on its high water solubility, removal from air via wet
deposition is likely to occur. Oxalic acid may also be removed from air via dry
deposition with 11% of the total deposition being dry deposition.
Other: Based on an average experimental water solubility of 220,000
mg/L at 25°C and a regression derived equation, the BCF for oxalic acid can be
estimated to be approximately 0.6 and therefore should not be expected to
bioconcentrate in aquatic organisms.
Section 13 - Disposal
Chemical waste generators
must determine whether a discarded chemical is classified as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR
Parts 261.3. Additionally, waste generators must consult state and local
hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 -
||CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (OXALIC ACID,
||CORROSIVE SOLID NOS (OXALIC ACID
Section 15 -
CAS# 144-62-7 is listed on the TSCA
CAS# 6153-56-6 is not on the TSCA Inventory. It is a hydrate and
exempt from TSCA Inventory requirements (40CFR720.3(u)(2)).
Safety Reporting List
None of the chemicals are on the Health &
Safety Reporting List.
Chemical Test Rules
None of the chemicals
in this product are under a Chemical Test Rule.
of the chemicals are listed under TSCA Section 12b.
TSCA Significant New
None of the chemicals in this material have a SNUR under TSCA.
Section 302 (RQ)
None of the chemicals in this
material have an RQ.
Section 302 (TPQ)
None of the chemicals in
this product have a TPQ.
CAS # 144-62-7: acute,
chronic. CAS # 6153-56-6: acute, chronic.
are reportable under Section 313.
Clean Air Act:
does not contain any hazardous air pollutants. This material does not contain
any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA. None of the chemicals in this
product are listed as Priority Pollutants under the CWA. None of the chemicals
in this product are listed as Toxic Pollutants under the CWA.
None of the chemicals in this product are considered highly
hazardous by OSHA.
CAS# 144-62-7 can be found on the
following state right to know lists: California, New Jersey, Florida,
Pennsylvania, Minnesota, Massachusetts.
CAS# 6153-56-6 can be found on the
following state right to know lists: Pennsylvania.
California No Significant
Risk Level: None of the chemicals in this product are listed.
European Labeling in
Accordance with EC Directives
R 21/22 Harmful in contact with skin and if
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 144-62-7: 1
CAS# 144-62-7 is listed on Canada's DSL List.
CAS# 144-62-7 is listed on Canada's DSL List. CAS# 144-62-7 is listed on
Canada's DSL List.
This product has a WHMIS classification of D1B, E.
CAS# 144-62-7 is listed on Canada's Ingredient Disclosure List.
6153-56-6 is not listed on Canada's Ingredient Disclosure List.
CAS# 144-62-7: OEL-ARAB Republic of Egypt:TWA 1 mg/m3
:TWA 1 mg/m3;STEL 2 mg/m3 OEL-BELGIUM:TWA 1 mg/m3;STEL 2 mg/m3
ENMARK:TWA 1 mg/m3 OEL-FINLAND:TWA 1 mg/m3;STEL 3 mg/m3
WA 1 mg/m3 OEL-THE NETHERLANDS:TWA 1 mg/m3 OEL-THE
mg/m3 OEL-SWITZERLAND:TWA 1 mg/m3 OEL-UNITED KINGDOM:TWA 1
EL 2 mg/m3 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
Section 16 -
MSDS Creation Date:
Revision #6 Date: 5/24/2001
The information above is
believed to be accurate and represents the best information currently available
to us. However, we make no warranty of merchantability or any other warranty,
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