Material Safety Data
Phenol, Reagent ACS
MSDS Name: Phenol, Reagent ACS
Section 1 - Chemical Product and Company
AC417170000, AC417170250, AC417175000
Synonyms: Carbolic acid;
Phenylic acid; Hydroxybenzene; Monohydroxybenzene; Phenyl hydroxide
Acros Organics N.V.
One Reagent Lane
For information in North America, call:
For emergencies in the US, call CHEMTREC:
Section 2 -
Composition, Information on Ingredients
Risk Phrases: 34 24/25
Section 3 - Hazards
Appearance: colourless. Flash Point: 79 deg C. Danger!
Corrosive. May cause central nervous system effects. May cause liver and kidney
damage. Harmful if swallowed or absorbed through the skin. May be harmful if
Combustible liquid and vapor. May cause central nervous system depression. Causes
eye and skin burns. May cause severe respiratory tract irritation with possible
burns. May cause severe digestive tract irritation with possible burns. This
substance has caused adverse reproductive and fetal effects in animals.
Target Organs: Kidneys, central nervous system, liver.
Potential Health Effects
Eye: Contact with liquid or vapor causes severe
burns and possible irreversible eye damage. May cause chemical conjunctivitis
and corneal damage.
Skin: Harmful if absorbed through the
skin. Direct skin contact results in white, wrinkled discoloration, followed by
severe burns. Phenol solutions may be absorbed through the skin ra pidly to
cause systemic poisoning and possible death.
Harmful if swallowed. May cause severe and permanent damage to the digestive
tract. May cause central nervous system depression, characterized by excitement,
followed by headache, dizziness, drowsiness, and nausea. Advanced stages may
cause collapse, unconsciousness, coma and possible death due to respiratory
failure. May cause perforation of the digestive tract. Causes digestive tract
burns with immediate pain, swelling of the throat, convulsions, and possible
Inhalation: Causes severe irritation of upper
respiratory tract with coughing, burns, breathing difficulty, and possible coma.
May be fatal if exposed to high concentrations. Aspiration may lead to pulmonary
edema. May also cause pallor, loss of appetite, nausea, vomiting, diarrhea,
weakness, darkened urine, headache, sweating, convulsions, cyanosis,
unconsciousness, fatigue, pulmonary edema and coma. Inhalation at high
concentrations may cause CNS depression and asphixiation.
Chronic: Chronic inhalation and ingestion may cause effects
similar to those of acute inhalation and ingestion. May cause liver and kidney
damage. May cause reproductive and fetal effects. Effects may be delayed.
Laboratory experiments have resulted in mutagenic effects. Repeated skin contact
may cause dermatitis with dark pigmentation of the skin. Animal studies have
reported the development of tumors.
Section 4 - First Aid
Eyes: Get medical aid immediately. Do NOT allow
victim to rub or keep eyes closed. Extensive irrigation with water is required
(at least 30 minutes).
Skin: Get medical aid immediately.
Immediately flush skin with plenty of soap and water for at least 15 minutes
while removing contaminated clothing and shoes. Wash clothing before reuse.
Discard contaminated clothing in a manner which limits further exposure. SPEEDY
ACTION IS CRITICAL! Destroy contaminated shoes.
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of
milk or water. Never give anything by mouth to an unconscious person. Get
medical aid immediately.
Inhalation: Get medical aid
immediately. Remove from exposure to fresh air immediately. If breathing is
difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing
has ceased apply artificial respiration using oxygen and a suitable mechanical
device such as a bag and a mask.
Notes to Physician:
Persons with liver or kidney disease should not be exposed to phenol for any
length of time.
Antidote: Activated charcoal, followed by
cathartic, may be preferred to ipecac induced emesis or lavage in
decontamination of the GI tract and preventing systemic absorption of phenol.
Section 5 - Fire
Information: As in any fire, wear a self-contained breathing apparatus
in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective
gear. During a fire, irritating and highly toxic gases may be generated by
thermal decomposition or combustion. Use water spray to keep fire-exposed
containers cool. Combustible Liquid. Containers may explode when heated.
Extinguishing Media: In case of fire, use water, dry
chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool
fire-exposed containers. Use agent most appropriate to extinguish fire.
Section 6 -
Accidental Release Measures
Information: Use proper personal protective equipment as indicated in
Spills/Leaks: Absorb spill with inert material
(e.g. vermiculite, sand or earth), then place in suitable container. Clean up
spills immediately, observing precautions in the Protective Equipment section.
Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Section 7 - Handling
Handling: Wash thoroughly after handling. Remove
contaminated clothing and wash before reuse. Use only in a well-ventilated area.
Do not get in eyes, on skin, or on clothing. Empty containers retain product
residue, (liquid and/or vapor), and can be dangerous. Keep container tightly
closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale.
Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill,
grind, or expose empty containers to heat, sparks or open flames.
Storage: Keep away from heat, sparks, and flame. Keep away
from sources of ignition. Keep container closed when not in use. Store in a
tightly closed container. Keep from contact with oxidizing materials. Store in a
cool, dry, well-ventilated area away from incompatible substances. Keep
refrigerated. (Store below 4°C/39°F.)
Section 8 - Exposure
Controls, Personal Protection
Controls: Use explosion-proof ventilation equipment. Facilities storing
or utilizing this material should be equipped with an eyewash facility and a
safety shower. Use adequate general or local exhaust ventilation to keep
airborne concentrations below the permissible exposure limits.
||5 ppm TWA; skin - potential for cutaneous absorption
||5 ppm TWA; 19 mg/m3 TWA 250 ppm IDLH
||5 ppm TWA; 19 mg/m3
OSHA Vacated PELs: Phenol: 5
ppm TWA; 19 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face protection regulations in 29
CFR 1910.133 or European Standard EN166.
neoprene gloves, apron, and/or clothing. Selection of specific glove materials
should be based on your conditions of use in your application in consultation
with your Safety Officer and manufacturer's glove recommendations. Many factors
influence the determination of proper glove material such as permeation rates
and break through time.
Clothing: Wear appropriate
protective clothing to prevent skin exposure.
respiratory protection program that meets OSHA's 29 CFR §1910.134 and ANSI Z88.2
requirements or European Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
Section 9 - Physical
and Chemical Properties
Odor: Sweet and tarry odor.
pH: Not available.
Vapor Pressure: 0.35 mm Hg @ 25 deg C
Vapor Density: 3.2
Evaporation Rate:<0.01 (butyl
Viscosity: Not available.
Boiling Point: 192
deg C @ 760.00 mmHg
Freezing/Melting Point:43 deg C
Autoignition Temperature: 605 deg C ( 1,121.00 deg F)
Point: 79 deg C ( 174.20 deg F)
NFPA Rating: (estimated) Health: 4; Flammability: 2;
Explosion Limits, Lower:1.30 vol %
9.50 vol %
Section 10 -
Stability and Reactivity
Stability: Stable under normal temperatures and pressures.
to Avoid: Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials: Strong oxidizing agents,
acids, isocyanates, acetaldehyde, nitrides (e.g. potassium nitride, sodium
nitride), calcium hypochlorite, peroxomonosulfuric acid, nitrobenzene, sodium
nitrite, aluminum chloride, peroxydisulfuric acid, 1,3-butadiene, boron
trifluoride diethyl ether.
Hazardous Decomposition Products: Carbon
monoxide, irritating and toxic fumes and gases, carbon dioxide.
Polymerization: Has not been reported.
Section 11 -
CAS# 108-95-2: SJ3325000
Draize test, rabbit, eye: 5 mg Severe;
Draize test, rabbit,
skin: 500 mg/24H Severe;
Draize test, rabbit, skin: 100 mg
Inhalation, mouse: LC50 = 177 mg/m3;
Inhalation, rat: LC50 = 316
Oral, mouse: LD50 = 270 mg/kg;
Oral, rat: LD50 = 317
Skin, rabbit: LD50 = 630 mg/kg;
Skin, rat: LD50 = 669
A4 - Not Classifiable as a Human Carcinogen
IARC: Group 3 carcinogen
Epidemiology: Administration onto the skin, mouse: TDLo = 16
gm/kg/40W-I (Tumorigenic - Carcinogenic by RTECS criteria - S kin and Appendages
Teratogenicity: Oral, rat: TDLo = 1200 mg/kg (female 6-15
day(s) after conception) Effects on Embryo or Fetus - fetotoxicity (except
death, e.g., stunted fetus).; Oral, mouse: TDLo = 4 gm/kg (female 6-15 day(s)
after conception) Specific Developmental Abnormalities - musculoskeletal system.
Reproductive Effects: Oral, rat: TDLo = 300 mg/kg (female 6-15 day(s)
after conception) Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants).
Mutagenicity: Mutation Test Systems - not otherwise
specified: Human, HeLa cell = 17 mg/L.; DNA Inhibition: Human, HeLa cell = 1
mmol/L.; Mutation Test Systems - not otherwise specified: Human, Lymphocyte = 5
umol/L.; Sister Chromatid Exchange: Human, Lymphocyte = 5 umol/L.
Studies: Standard Draize Test: Administration onto the skin (rabbit) = 500
mg/24H (Severe). Standard Draize Test: Administra tion into the eye (rabbit) = 5
Section 12 -
Water flea Daphnia: EC50=12 mg/l; 48-hour; CAS# 108-95-2: Unspecified flea
Daphnia: EC50=4.0 mg/l; 96-hour; CAS# 108-95-2: Unspecified Fathead Minnow: LC50
> 50 mg/l; 1 Hr; CAS# 108-95-2 Static @ 18-22°C Fathead Minnow: TLm = 41
mg/L; 48-hour; CAS# 108-95-2: Flow-through @ 15°C Bluegill/Sunfish: TLm = 19 /
5.7 mg/L; 96 Hr; CAS# 108-95-2: Flow-through If released to the environment,
phenol's primary removal mechanism is biodegradation which is generally rapid
(days). If phenol is released to soil, it will readily leach and biodegrade. The
biodegradation in soil is generally rapid with half-lives of under 5 days even
in subsurface soils.
Environmental: Phenol does not bioconcentrate in
aquatic organisms. In the atmosphere, phenol occurs as a vapor and reacts with
photochemically-produced hydroxyl radicals resulting in a half-life of
approximately 15 hours. During the nighttime, it reacts with nitrate radicals
with a resulting half-life of 12 minutes. Phenol has also been shown to be
readily removed from the atmosphere by rain.
Physical: No information
Other: No information available.
Section 13 - Disposal
Chemical waste generators
must determine whether a discarded chemical is classified as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR
Parts 261.3. Additionally, waste generators must consult state and local
hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 108-95-2:
waste number U188.
Section 14 -
Section 15 -
CAS# 108-95-2 is listed on the TSCA
Health & Safety Reporting List
Effective date: June 1, 1987; Sunset Date: June 1, 1997
None of the chemicals in this product are under a Chemical Test
None of the chemicals are listed under TSCA
TSCA Significant New Use Rule
None of the chemicals
in this material have a SNUR under TSCA.
CAS# 108-95-2: final RQ = 1000 pounds (454 kg)
CAS# 108-95-2: TPQ = 500/10,000 pounds; RQ = 1000 pounds
CAS # 108-95-2: acute, chronic, flammable.
This material contains Phenol (CAS# 108-95-2,
100%),which is subject to the reporting requirements of Section 313 of SARA
Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 108-95-2 is
listed as a hazardous air pollutant (HAP). This material does not contain any
Class 1 Ozone depletors. This material does not contain any Class 2 Ozone
Clean Water Act:
CAS# 108-95-2 is listed as a Hazardous
Substance under the CWA. CAS# 108-95-2 is listed as a Priority Pollutant under
the Clean Water Act. CAS# 108-95-2 is listed as a Toxic Pollutant under the
Clean Water Act.
None of the chemicals in this product are
considered highly hazardous by OSHA.
CAS# 108-95-2 can be
found on the following state right to know lists: California, New Jersey,
Florida, Pennsylvania, Minnesota, Massachusetts.
California No Significant
Risk Level: None of the chemicals in this product are listed.
European Labeling in
Accordance with EC Directives
R 34 Causes burns.
R 24/25 Toxic in contact with skin and if
S 1/2 Keep locked up and out of
reach of children.
S 28 After contact with skin, wash immediately
S 45 In case of accident or if you feel unwell, seek
advice immediately (show the label where
CAS# 108-95-2: 2
CAS# 108-95-2 is
listed on Canada's DSL List. CAS# 108-95-2 is listed on Canada's DSL List.
This product has a WHMIS classification of E, D1A, B3, D2A.
108-95-2 is listed on Canada's Ingredient Disclosure List.
CAS# 108-95-2: OEL-ARAB Republic of Egypt:TWA 5 ppm (19
OEL-AUSTRALIA:TWA 5 ppm (19 mg/m3);Skin OEL-BELGIUM:TWA 5 ppm
/m3);Skin OEL-CZECHOSLOVAKIA:TWA 20 mg/m3;STEL 40 mg/m3
TWA 5 ppm (19 mg/m3);Skin OEL-FINLAND:TWA 5 ppm (19 mg/m3);STEL
m (38 mg/m3);Skin OEL-FRANCE:TWA 5 ppm (19 mg/m3);Skin
WA 5 ppm (19 mg/m3);Skin OEL-HUNGARY:TWA 4 mg/m3;STEL 8
EL-JAPAN:TWA 5 ppm (19 mg/m3);Skin OEL-THE NETHERLANDS:TWA 5 ppm
mg/m3);Skin OEL-THE PHILIPPINES:TWA 5 ppm (10 mg/m3);Skin
:TWA 10 ppm OEL-RUSSIA:TWA 5 ppm;STEL 0.3 mg/m3;Skin
1 ppm (4 mg/m3);STEL 2 ppm (8 mg/m3);Skin OEL-SWITZERLAND:TWA
5 ppm (
19 mg/m3);STEL 10 ppm (38 mg/m3);Skin OEL-THAILAND:TWA 5 ppm (19
3) OEL-TURKEY:TWA 5 ppm (19 mg/m3);Skin OEL-UNITED KINGDOM:TWA 5
(19 mg/m3);STEL 10 ppm;Skin OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA
check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TL
Section 16 -
MSDS Creation Date:
Revision #3 Date: 4/06/2001
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