Material Safety Data Sheet
Ninhydrin, reagent ACS

ACC# 01021
Section 1 - Chemical Product and Company Identification
MSDS Name: Ninhydrin, reagent ACS
Catalog Numbers: AC415720000, AC415720100, AC415720250
Synonyms:
1,2,3-Indantrione; 1,2,3-Triketohydrindene; 2,2-Dihydroxy-1,3-indandione; 2,2-Dihydroxy-1H-indene-1,3(2H)-dione; 1H-Indene-1,2,3-trione.
Company Identification:

              Acros Organics N.V.
              One Reagent Lane
              Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
485-47-2 Ninhydrin 100.0 207-618-1

Hazard Symbols:
XN
Risk Phrases:
22 36/37/38

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: slightly yellow. Light sensitive. Causes eye and skin irritation. Warning! Causes respiratory tract irritation. Harmful if swallowed. May be harmful if absorbed through skin or if inhaled.
Target Organs: Eyes, skin, mucous membranes.


Potential Health Effects
Eye: Causes eye irritation.
Skin: Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May be harmful if absorbed through the skin. May cause reddening of the skin.
Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation: The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled. Inhalation of dust causes respiratory tract irritation with cough and sore throat.
Chronic: No information found.

Section 4 - First Aid Measures


Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin: In case of contact, immediately flush skin with soap and plenty of water. Remove contaminated clothing and shoes. Get medical aid if symptoms occur. Wash clothing before reuse.
Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.

Section 7 - Handling and Storage


Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage: Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light. Refrigeration has been recommended.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Ninhydrin none listed none listed none listed

OSHA Vacated PELs: Ninhydrin: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 9 - Physical and Chemical Properties


Physical State: Crystalline powder
Appearance: slightly yellow
Odor: characteristic odor
pH: Not available.
Vapor Pressure: Negligible.
Vapor Density: 6.16 (air=1)
Evaporation Rate:Not applicable.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:466 deg F (dec)
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Decomposition Temperature:466 deg F
NFPA Rating: (estimated) Health: 2; Flammability: 1; Reactivity: 0
Explosion Limits, Lower:Not available.
Upper: Not available.
Solubility: Soluble in water.
Specific Gravity/Density:0.86
Molecular Formula:C9H6O4
Molecular Weight:178.14

Section 10 - Stability and Reactivity


Chemical Stability: Stable under normal temperatures and pressures. May discolor on exposure to light. Ninhydrin becomes anhydrous with reddening at 257F, swells at 282F and decomposes at 466F. Ninhydrin is sensitive to prolonged exposure to light. UV spectrophotometric stability screening indicates that solutions of this compound in ethanol are stable for at least 24 hours.
Conditions to Avoid: High temperatures, light, dust generation.
Incompatibilities with Other Materials: Strong oxidizing agents, bases, amines.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information


RTECS#:
CAS# 485-47-2: NK5425000
LD50/LC50:
Not available.

Carcinogenicity:
CAS# 485-47-2: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology: No information found.
Teratogenicity: No information found.
Reproductive Effects: No information found.
Neurotoxicity: No information found.
Mutagenicity: No information found.
Other Studies: See actual entry in RTECS for complete information.

Section 12 - Ecological Information


Ecotoxicity: No data available. No information available.
Environmental: No information available.
Physical: Log P (octanol-water): 0.67
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT IATA RID/ADR IMO Canada TDG
Shipping Name: No information available. No information available.
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information

US FEDERAL

TSCA
CAS# 485-47-2 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA

Section 302 (RQ)
None of the chemicals in this material have an RQ.
Section 302 (TPQ)
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 485-47-2: acute.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 485-47-2 is not present on state lists from CA, PA, MN, MA, FL, or NJ.
California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:

R 22 Harmful if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.

Safety Phrases:

S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.

WGK (Water Danger/Protection)

CAS# 485-47-2: 2
Canada
CAS# 485-47-2 is listed on Canada's DSL List. CAS# 485-47-2 is listed on Canada's DSL List.
This product has a WHMIS classification of D1B, D2B.
CAS# 485-47-2 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits

Section 16 - Additional Information

MSDS Creation Date: 9/23/1998
Revision #3 Date: 11/17/2000
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.