Material Safety Data
Section 1 - Chemical Product and Company
MSDS Name: Caffeine
Catalog Numbers: S79939, O1728 500, O1728-500, O1728500
Xanthrine,1,3,7-Trimethyl; Anhydrous Caffeine; Methyl Theobromide
Fair Lawn, NJ 07410
For information, call: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
International CHEMTREC assistance, call: 703-527-3887
Section 2 -
Composition, Information on Ingredients
Risk Phrases: 22
Section 3 - Hazards
Appearance: white. Warning! Harmful if swallowed. May cause
cancer based on animal studies. May cause cardiac disturbances. May cause eye
and skin irritation. May cause respiratory tract irritation. May cause digestive
tract irritation with nausea, vomiting, and diarrhea. Can cause adverse
reproductive effects. May cause central nervous system effects.
Target Organs: Heart, central nervous system.
Potential Health Effects
Eye: Dust may cause mechanical irritation.
Skin: May cause skin irritation.
Ingestion: Harmful if swallowed. May cause gastrointestinal
irritation with nausea, vomiting and diarrhea. Ingestion increases the metabolic
rate causing warm, flushed and moist skin, muscular weakness, rapid heart rate,
insomnia, nervousness, increased metabolism and weight loss. May cause ataxia,
blood pressure elevation, convulsions, hallucinations, hypermotility, muscle
contraction or spasticity, somnolence (general depressed activity), toxic
psychosis, and tremors.
Inhalation: May cause respiratory
tract irritation. May cause effects similar to those described for ingestion.
Chronic: May cause cancer according to animal studies. May
cause digestive tract and cardiac disturbances. May cause reproductive and fetal
Section 4 - First Aid
Eyes: Flush eyes with plenty of water for at least
15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Flush skin with plenty of soap and water for at least
15 minutes while removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists. Wash clothing before reuse.
Ingestion: Induce vomiting. If victim is conscious and
alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Inhalation: Remove from exposure to fresh air immediately.
If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical aid.
Notes to Physician: Treat
symptomatically and supportively.
Section 5 - Fire
Information: As in any fire, wear a self-contained breathing apparatus
in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective
gear. During a fire, irritating and highly toxic gases may be generated by
thermal decomposition or combustion.
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant
foam. Use agent most appropriate to extinguish fire.
Section 6 -
Accidental Release Measures
Information: Use proper personal protective equipment as indicated in
Spills/Leaks: Clean up spills immediately,
observing precautions in the Protective Equipment section. Sweep up, then place
into a suitable container for disposal. Avoid generating dusty conditions.
Section 7 - Handling
Handling: Wash hands before eating. Use with
adequate ventilation. Minimize dust generation and accumulation. Avoid contact
with skin and eyes. Do not ingest or inhale. Wash clothing before reuse.
Storage: Store in a tightly closed container. Store in a
cool, dry, well-ventilated area away from incompatible substances.
Section 8 - Exposure
Controls, Personal Protection
Controls: Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended exposure
OSHA Vacated PELs:
CAFFEINE: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Skin: Wear appropriate protective gloves to
prevent skin exposure.
Clothing: Wear appropriate
protective clothing to minimize contact with skin.
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European
Standard EN 149. Always use a NIOSH or European Standard EN 149 approved
respirator when necessary.
Section 9 - Physical
and Chemical Properties
Vapor Pressure: Negligible.
Vapor Density: Not
Boiling Point: 352 deg F
Point:460 deg F
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
NFPA Rating: (estimated) Health: 2; Flammability: 0;
Explosion Limits, Lower:Not available.
Upper: Not available.
Solubility: Slightly soluble in
Section 10 -
Stability and Reactivity
Stability: Stable at room temperature in closed containers under normal
storage and handling conditions.
Conditions to Avoid: Incompatible
materials, dust generation, excess heat.
Incompatibilities with Other
Materials: Strong oxidizing agents.
Products: Nitrogen oxides, carbon monoxide, irritating and toxic fumes and
gases, carbon dioxide.
Hazardous Polymerization: Has not been
Section 11 -
CAS# 58-08-2: EV6475000
Oral, mouse: LD50 = 127 mg/kg;
Oral, rabbit: LD50 = 224
Oral, rat: LD50 = 192 mg/kg;
IARC: Group 3 carcinogen
Epidemiology: Experimental reproductive effects have been reported.
Teratogenicity: A human teratogen, causes developmental abnormalities
of the craniofacial and musculoskeletal systems, pregnancy termination and
Reproductive Effects: See above.
Neurotoxicity: No information available.
Other Studies: See actual entry in RTECS for
Section 12 -
data available. No information available.
FATE: If released to soil, estimated soil adsorption indicate that caffeine will
display very high mobility. An estimated Henry's Law constant of 1.9X10-19
atm-cu m/mole at 25 deg C indicates that it will not volatilize from moist soil
to the atmosphere. AQUATIC FATE: If released to water caffiene will not
bioconcentrate aquatic organisms. ATMOSPHERIC FATE: Exists predominantly in the
particulate phase, half life 2.5 hours. Expected to biodegrade but not
Physical: No information available.
No information available.
Section 13 - Disposal
Chemical waste generators
must determine whether a discarded chemical is classified as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR
Parts 261.3. Additionally, waste generators must consult state and local
hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 -
||ALKALOIDS, SOLID, N.O.S. (CAFFEINE)
||ALKALOIDS, SOLID,NOS (CAFFEINE)|
Section 15 -
CAS# 58-08-2 is listed on the TSCA
Health & Safety Reporting List
None of the
chemicals are on the Health & Safety Reporting List.
None of the chemicals in this product are under a Chemical Test
None of the chemicals are listed under TSCA
TSCA Significant New Use Rule
None of the chemicals
in this material have a SNUR under TSCA.
None of the chemicals in this material have an RQ.
None of the chemicals in this product have a TPQ.
CAS # 58-08-2: acute.
No chemicals are
reportable under Section 313.
Clean Air Act:
This material does
not contain any hazardous air pollutants. This material does not contain any
Class 1 Ozone depletors. This material does not contain any Class 2 Ozone
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA. None of the chemicals in this
product are listed as Priority Pollutants under the CWA. None of the chemicals
in this product are listed as Toxic Pollutants under the CWA.
None of the chemicals in this product are considered highly
hazardous by OSHA.
CAS# 58-08-2 is not present on state
lists from CA, PA, MN, MA, FL, or NJ.
California No Significant Risk Level:
None of the chemicals in this product are listed. European/International
European Labeling in Accordance with EC
Harmful if swallowed.
CAS# 58-08-2: 1
CAS# 58-08-2 is
listed on Canada's DSL List. CAS# 58-08-2 is listed on Canada's DSL List.
This product has a WHMIS classification of D1B, D2B.
CAS# 58-08-2 is not
listed on Canada's Ingredient Disclosure List.
CAS# 58-08-2: OEL-RUSSIA:STEL 0.5 mg/m3
Section 16 -
MSDS Creation Date:
Revision #1 Date: 8/02/2000
The information above is
believed to be accurate and represents the best information currently available
to us. However, we make no warranty of merchantability or any other warranty,
express or implied, with respect to such information, and we assume no liability
resulting from its use. Users should make their own investigations to determine
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shall Fisher be liable for any claims, losses, or damages of any third party or
for lost profits or any special, indirect, incidental, consequential or
exemplary damages, howsoever arising, even if Fisher has been advised of the
possibility of such damages.