Material Safety Data Sheet
Acetic anhydride

ACC# 00130
Section 1 - Chemical Product and Company Identification

MSDS Name: Acetic anhydride
Catalog Numbers: AC400060000, AC400060010, AC400060040, S70072, S70078, S71903, A10-1, A10-100, A10-4, A10-500, A10J4, NC9556617, S75249, XXA10207LI
Synonyms:
Acetic oxide; Acetyl oxide; Ethanoic anhydride; Acetic acid anhydride.
Company Identification:

              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
For information, call:
201-796-7100
Emergency Number:
201-796-7100
For CHEMTREC assistance, call:
800-424-9300
For International CHEMTREC assistance, call:
703-527-3887

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
108-24-7 Acetic anhydride > 97.0 203-564-8

Hazard Symbols:
C
Risk Phrases:
10 20/22 34

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: colorless liquid. Flash Point: 126 deg F. Danger! Corrosive. Causes digestive and respiratory tract burns. Flammable liquid and vapor. May be harmful if swallowed. May cause central nervous system depression. Causes eye and skin burns. Harmful if inhaled. Moisture sensitive.
Target Organs: Central nervous system, eyes, skin, mucous membranes.


Potential Health Effects
Eye: Eye damage may be delayed. Contact with liquid is corrosive to the eyes and causes severe burns. When substance becomes wet or comes in contact with moisture of the mucous membranes, it will cause irritation. May cause chemical conjunctivitis and corneal damage.
Skin: Contact with skin causes irritation and possible burns, especially if the skin is wet or moist. Prolonged skin contact may be painless with reddening of the skin followed be a white appearance of the skin. Skin burns may be delayed. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion: May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May be harmful if swallowed. Ingestion of large amounts may cause CNS depression. May cause systemic effects.
Inhalation: Harmful if inhaled. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. Causes chemical burns to the respiratory tract. May cause lung damage. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause systemic effects. May cause burning sensation in the chest.
Chronic: Effects may be delayed. Prolonged skin contact may be painless and cause redness and subsequently a white appearance of the skin accompanied by wrinkling. Skin burns may be delayed.

Section 4 - First Aid Measures


Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid immediately. Wash clothing before reuse.
Ingestion: If swallowed, do NOT induce vomiting. Get medical aid immediately. If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Wear appropriate protective clothing to prevent contact with skin and eyes. Wear a self-contained breathing apparatus (SCBA) to prevent contact with thermal decomposition products. Containers may explode in the heat of a fire. Flammable liquid and vapor. May ignite or explode on contact with steam or moist air.
Extinguishing Media: Use dry sand or earth to smother fire. If water is the only media available, use in flooding amounts. DO NOT USE WATER! Do NOT use straight streams of water. Contact professional fire-fighters immediately. Cool containers with flooding quantities of water until well after fire is out.

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not expose spill to water. Spill may be neutralized with lime. Cover with material such as dry soda ash or calcium carbonate and place into a closed container for disposal. A vapor suppressing foam may be used to reduce vapors.

Section 7 - Handling and Storage


Handling: Remove contaminated clothing and wash before reuse. Do not allow water to get into the container because of violent reaction. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Use with adequate ventilation. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam.
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Do not store in direct sunlight. Keep container closed when not in use. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Flammables-area.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Acetic anhydride 5 ppm TWA 200 ppm IDLH 5 ppm TWA; 20 mg/m3 TWA

OSHA Vacated PELs: Acetic anhydride: C 5 ppm; C 20 mg/m3
Personal Protective Equipment
Eyes: Wear chemical goggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Section 9 - Physical and Chemical Properties


Physical State: Liquid
Appearance: colorless liquid
Odor: strong odor - pungent odor - acetic odor
pH: Not available.
Vapor Pressure: 3.9 mm Hg @68F
Vapor Density: 3.5 (air=1)
Evaporation Rate:0.46 (n-butyl acetate=1)
Viscosity: Not available.
Boiling Point: 137 deg C
Freezing/Melting Point:Not available.
Autoignition Temperature: 630 deg F ( 332.22 deg C)
Flash Point: 126 deg F ( 52.22 deg C)
Decomposition Temperature:Not available.
NFPA Rating: (estimated) Health: 3; Flammability: 2; Reactivity: 1
Explosion Limits, Lower:2.9%
Upper: 10.3%
Solubility: Decomposes.
Specific Gravity/Density:1.0820g/cm3
Molecular Formula:C4H6O3
Molecular Weight:102.09

Section 10 - Stability and Reactivity


Chemical Stability: Stable. However, may decompose if exposed to moist air or water. Substance is readily hydrolyzed. Reacts with water to form corresponding acid.
Conditions to Avoid: Ignition sources, contact with water, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials: Strong oxidizing agents, strong reducing agents, bases, alcohols, metal powders, moisture.
Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information


RTECS#:
CAS# 108-24-7: AK1925000
LD50/LC50:
CAS# 108-24-7:
Inhalation, rat: LC50 = 1000 ppm/4H;
Oral, rat: LD50 = 1780 mg/kg;
Skin, rabbit: LD50 = 4 mL/kg;
Carcinogenicity:
CAS# 108-24-7: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology: No information found.
Teratogenicity: No information found.
Reproductive Effects: No information found.
Neurotoxicity: No information found.
Mutagenicity: No information found.
Other Studies: See actual entry in RTECS for complete information.

Section 12 - Ecological Information


Ecotoxicity: No data available. No information available.
Environmental: Terrestrial: Will readily infiltrate downward toward ground water. Aquatic: Will react slowly and become miscible, and will produce an irritating vapor. Mixing takes place and the spill is diluted. In rivers, the principal mixing agent is stream turbulence. Atmospheric: Since acetic anhydride is a relatively non-volatile liquid, direct venting of the vapor to the atmosphere from a hole in a ruptured vessel does not consitiute a significant hazard downwind. Only vapor released from a liquid pool spilled on a ground or water surfaces is important.
Physical: Not expected to bioconcentrate or biodegrade.
Other: For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND EXPOSURE DATA."

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT IATA RID/ADR IMO Canada TDG
Shipping Name: ACETIC ANHYDRIDE ACETIC ACID SOLUTION
Hazard Class: 8 8(9.2)
UN Number: UN1715 UN2790
Packing Group: II II

Section 15 - Regulatory Information

US FEDERAL

TSCA
CAS# 108-24-7 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA

Section 302 (RQ)
CAS# 108-24-7: final RQ = 5000 pounds (2270 kg)
Section 302 (TPQ)
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 108-24-7: acute, chronic, flammable, reactive.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 108-24-7 is listed as a Hazardous Substance under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 108-24-7 can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts.
California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
C
Risk Phrases:

R 10 Flammable.
R 20/22 Harmful by inhalation and if swallowed.
R 34 Causes burns.

Safety Phrases:

S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).

WGK (Water Danger/Protection)

CAS# 108-24-7: 1
Canada
CAS# 108-24-7 is listed on Canada's DSL List. CAS# 108-24-7 is listed on Canada's DSL List.
This product has a WHMIS classification of B3, D1B, D2B, E.
CAS# 108-24-7 is listed on Canada's Ingredient Disclosure List.
Exposure Limits

Section 16 - Additional Information

MSDS Creation Date: 10/09/1998
Revision #11 Date: 10/05/2001
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.