Material Safety Data
Section 1 - Chemical Product and Company
MSDS Name: Acetic anhydride
Catalog Numbers: AC400060000, AC400060010, AC400060040,
S70072, S70078, S71903, A10-1, A10-100, A10-4, A10-500, A10J4, NC9556617,
Synonyms: Acetic oxide; Acetyl oxide; Ethanoic
anhydride; Acetic acid anhydride.
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call:
Emergency Number: 201-796-7100
assistance, call: 800-424-9300
For International CHEMTREC assistance,
Section 2 -
Composition, Information on Ingredients
Risk Phrases: 10 20/22 34
Section 3 - Hazards
Appearance: colorless liquid. Flash Point: 126 deg F.
Danger! Corrosive. Causes digestive and respiratory tract
Flammable liquid and vapor. May be harmful if swallowed. May cause central nervous
system depression. Causes eye and skin burns. Harmful if inhaled. Moisture
Target Organs: Central nervous system, eyes,
skin, mucous membranes.
Eye: Eye damage may be delayed.
Contact with liquid is corrosive to the eyes and causes severe burns. When
substance becomes wet or comes in contact with moisture of the mucous membranes,
it will cause irritation. May cause chemical conjunctivitis and corneal damage.
Skin: Contact with skin causes irritation and possible
burns, especially if the skin is wet or moist. Prolonged skin contact may be
painless with reddening of the skin followed be a white appearance of the skin.
Skin burns may be delayed. May cause cyanosis of the extremities. May cause skin
rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion: May cause severe and permanent damage to the
digestive tract. Causes gastrointestinal tract burns. May cause perforation of
the digestive tract. May be harmful if swallowed. Ingestion of large amounts may
cause CNS depression. May cause systemic effects.
Inhalation: Harmful if inhaled. Causes severe irritation of
upper respiratory tract with coughing, burns, breathing difficulty, and possible
coma. Causes chemical burns to the respiratory tract. May cause lung damage.
Aspiration may lead to pulmonary edema. Vapors may cause dizziness or
suffocation. May cause systemic effects. May cause burning sensation in the
Chronic: Effects may be delayed. Prolonged skin
contact may be painless and cause redness and subsequently a white appearance of
the skin accompanied by wrinkling. Skin burns may be delayed.
Section 4 - First Aid
Eyes: In case of contact, immediately flush eyes
with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin: In case of contact, immediately flush skin with
plenty of water for at least 15 minutes while removing contaminated clothing and
shoes. Get medical aid immediately. Wash clothing before reuse.
Ingestion: If swallowed, do NOT induce vomiting. Get
medical aid immediately. If victim is fully conscious, give a cupful of water.
Never give anything by mouth to an unconscious person.
Inhalation: If inhaled, remove to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid.
Notes to Physician: Treat symptomatically
Section 5 - Fire
Information: As in any fire, wear a self-contained breathing apparatus
in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective
gear. Vapors may form an explosive mixture with air. Vapors can travel to a
source of ignition and flash back. During a fire, irritating and highly toxic
gases may be generated by thermal decomposition or combustion. Water Reactive.
Material will react with water and may release a flammable and/or toxic gas. Use
water spray to keep fire-exposed containers cool. Wear appropriate protective
clothing to prevent contact with skin and eyes. Wear a self-contained breathing
apparatus (SCBA) to prevent contact with thermal decomposition products.
Containers may explode in the heat of a fire. Flammable liquid and vapor. May
ignite or explode on contact with steam or moist air.
Media: Use dry sand or earth to smother fire. If water is the only
media available, use in flooding amounts. DO NOT USE WATER! Do NOT use straight
streams of water. Contact professional fire-fighters immediately. Cool
containers with flooding quantities of water until well after fire is out.
Section 6 -
Accidental Release Measures
Information: Use proper personal protective equipment as indicated in
Spills/Leaks: Absorb spill with inert material
(e.g. vermiculite, sand or earth), then place in suitable container. Avoid
runoff into storm sewers and ditches which lead to waterways. Clean up spills
immediately, observing precautions in the Protective Equipment section. Remove
all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not
expose spill to water. Spill may be neutralized with lime. Cover with material
such as dry soda ash or calcium carbonate and place into a closed container for
disposal. A vapor suppressing foam may be used to reduce vapors.
Section 7 - Handling
Handling: Remove contaminated clothing and wash
before reuse. Do not allow water to get into the container because of violent
reaction. Ground and bond containers when transferring material. Use spark-proof
tools and explosion proof equipment. Do not breathe dust, vapor, mist, or gas.
Do not get in eyes, on skin, or on clothing. Empty containers retain product
residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat,
sparks and flame. Use with adequate ventilation. Discard contaminated shoes. Do
not pressurize, cut, weld, braze, solder, drill, grind, or expose empty
containers to heat, sparks or open flames. Keep from contact with moist air and
Storage: Keep away from heat, sparks, and flame.
Keep away from sources of ignition. Do not store in direct sunlight. Keep
container closed when not in use. Keep from contact with oxidizing materials.
Store in a cool, dry, well-ventilated area away from incompatible substances.
Keep away from water. Flammables-area.
Section 8 - Exposure
Controls, Personal Protection
Controls: Facilities storing or utilizing this material should be
equipped with an eyewash facility and a safety shower. Use adequate general or
local explosion-proof ventilation to keep airborne levels to acceptable levels.
||5 ppm TWA
||200 ppm IDLH
||5 ppm TWA; 20 mg/m3
OSHA Vacated PELs: Acetic
anhydride: C 5 ppm; C 20 mg/m3
Eyes: Wear chemical goggles.
Skin: Wear appropriate protective gloves to prevent skin
Clothing: Wear appropriate protective clothing to
prevent skin exposure.
Respirators: A respiratory protection program
that meets OSHA's 29 CFR §1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace conditions warrant a
Section 9 - Physical
and Chemical Properties
Appearance: colorless liquid
Odor: strong odor -
pungent odor - acetic odor
pH: Not available.
Pressure: 3.9 mm Hg @68F
Vapor Density: 3.5 (air=1)
Evaporation Rate:0.46 (n-butyl acetate=1)
Boiling Point: 137 deg C
Autoignition Temperature: 630 deg F ( 332.22
Flash Point: 126 deg F ( 52.22 deg C)
NFPA Rating: (estimated) Health: 3;
Flammability: 2; Reactivity: 1
Explosion Limits, Lower:2.9%
Section 10 -
Stability and Reactivity
Stability: Stable. However, may decompose if exposed to moist air or water.
Substance is readily hydrolyzed. Reacts with water to form corresponding acid.
Conditions to Avoid: Ignition sources, contact with water, excess
heat, exposure to moist air or water.
Incompatibilities with Other
Materials: Strong oxidizing agents, strong reducing agents, bases, alcohols,
metal powders, moisture.
Hazardous Decomposition Products: Carbon
monoxide, irritating and toxic fumes and gases, carbon dioxide.
Polymerization: Has not been reported.
Section 11 -
CAS# 108-24-7: AK1925000
Inhalation, rat: LC50 = 1000 ppm/4H;
Oral, rat: LD50 = 1780
Skin, rabbit: LD50 = 4 mL/kg;
CAS# 108-24-7: Not listed by ACGIH, IARC, NIOSH,
NTP, or OSHA.
Epidemiology: No information found.
Teratogenicity: No information found.
Effects: No information found.
Neurotoxicity: No information
Mutagenicity: No information found.
See actual entry in RTECS for complete information.
Section 12 -
data available. No information available.
Will readily infiltrate downward toward ground water. Aquatic: Will react slowly
and become miscible, and will produce an irritating vapor. Mixing takes place
and the spill is diluted. In rivers, the principal mixing agent is stream
turbulence. Atmospheric: Since acetic anhydride is a relatively non-volatile
liquid, direct venting of the vapor to the atmosphere from a hole in a ruptured
vessel does not consitiute a significant hazard downwind. Only vapor released
from a liquid pool spilled on a ground or water surfaces is important.
Physical: Not expected to bioconcentrate or biodegrade.
Other: For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND
Section 13 - Disposal
Chemical waste generators
must determine whether a discarded chemical is classified as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR
Parts 261.3. Additionally, waste generators must consult state and local
hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 -
||ACETIC ACID SOLUTION|
Section 15 -
CAS# 108-24-7 is listed on the TSCA
Health & Safety Reporting List
None of the
chemicals are on the Health & Safety Reporting List.
None of the chemicals in this product are under a Chemical Test
None of the chemicals are listed under TSCA
TSCA Significant New Use Rule
None of the chemicals
in this material have a SNUR under TSCA.
CAS# 108-24-7: final RQ = 5000 pounds (2270 kg)
None of the chemicals in this product have a TPQ.
CAS # 108-24-7: acute, chronic, flammable, reactive.
No chemicals are reportable under Section 313.
This material does not contain any hazardous air pollutants. This
material does not contain any Class 1 Ozone depletors. This material does not
contain any Class 2 Ozone depletors.
Clean Water Act:
108-24-7 is listed as a Hazardous Substance under the CWA. None of the chemicals
in this product are listed as Priority Pollutants under the CWA. None of the
chemicals in this product are listed as Toxic Pollutants under the CWA.
None of the chemicals in this product are considered highly
hazardous by OSHA.
CAS# 108-24-7 can be found on the
following state right to know lists: California, New Jersey, Florida,
Pennsylvania, Minnesota, Massachusetts.
California No Significant Risk
Level: None of the chemicals in this product are listed.
European Labeling in
Accordance with EC Directives
R 10 Flammable.
R 20/22 Harmful by inhalation and if
R 34 Causes burns.
S 26 In case
of contact with eyes, rinse immediately
with plenty of water and seek
S 36/37/39 Wear suitable protective clothing, gloves
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
WGK (Water Danger/Protection)
CAS# 108-24-7: 1
CAS# 108-24-7 is listed on Canada's DSL List. CAS# 108-24-7
is listed on Canada's DSL List.
This product has a WHMIS classification of
B3, D1B, D2B, E.
CAS# 108-24-7 is listed on Canada's Ingredient Disclosure
Section 16 -
MSDS Creation Date:
Revision #11 Date: 10/05/2001
The information above is
believed to be accurate and represents the best information currently available
to us. However, we make no warranty of merchantability or any other warranty,
express or implied, with respect to such information, and we assume no liability
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