Caffeine
03830
**** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****
MSDS Name: Caffeine
Catalog Numbers:
O1728 500, O1728-500, O1728500
Synonyms:
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Company Identification: Fisher Scientific
1 Reagent Lane
Fairlawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 58-08-2 |CAFFEINE | 100 | 200-362-1 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Appearance: White powder.
Warning! May cause respiratory tract irritation. Harmful if
swallowed. May cause eye and skin irritation. May cause cardiac
disturbances. Can cause reproductive effects. May cause digestive
tract irritation with nausea, vomiting, and diarrhea. May cause
cancer based on animal studies.
Target Organs: Heart, central nervous system.
Potential Health Effects
Eye:
Dust may cause mechanical irritation.
Skin:
May cause skin irritation.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with
nausea, vomiting and diarrhea.
May cause ataxia, blood pressure elevation, convulsions,
hallucinations, hypermotility, muscle contraction or spasticity,
somnolence (general depressed activity), toxic psychosis, and
tremors.
Inhalation:
May cause respiratory tract irritation. May cause effects similar to
those described for ingestion.
Chronic:
May cause cancer according to animal studies. May cause digestive
tract and cardiac disturbances. May cause reproductive and fetal
effects.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower lids. Get medical aid.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes
while removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists.
Ingestion:
Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls
of milk or water. Never give anything by mouth to an unconscious
person. Get medical aid immediately.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
NFPA Rating: Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Sweep up, then place into a suitable container for disposal. Avoid
generating dusty conditions.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash hands before eating. Use with adequate ventilation. Avoid
contact with skin and eyes. Do not ingest or inhale.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits.
Exposure Limits
+--------------------+-------------------+-------------------+-----------------+
| Chemical Name | ACGIH | NIOSH |OSHA - Final PELs|
|--------------------|-------------------|-------------------|-----------------|
| CAFFEINE |none listed |none listed |none listed |
+--------------------+-------------------+-------------------+-----------------+
OSHA Vacated PELs:
CAFFEINE:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29CFR
1910.134. Always use a NIOSH-approved respirator when
necessary.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Solid
Appearance: White powder.
Odor: Odorless.
pH: Not available.
Vapor Pressure: Negligible.
Vapor Density: Not available.
Evaporation Rate: Negligible.
Viscosity: Not available.
Boiling Point: 352F
Freezing/Melting Point: 460F
Decomposition Temperature: Not available.
Solubility: Slightly soluble in water.
Specific Gravity/Density: 1.23
Molecular Formula: C8H10N4O2
Molecular Weight: 194.0956
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 58-08-2: EV6475000
LD50/LC50:
CAS# 58-08-2: Oral, mouse: LD50 = 127 mg/kg; Oral, rabbit: LD50 =
224 mg/kg; Oral, rat: LD50 = 192 mg/kg.
Carcinogenicity:
CAFFEINE -
IARC: Group 3 carcinogen
Epidemiology:
No data available.
Teratogenicity:
A human teratogen, causes developmental abnormalities of the
craniofacial and musculoskeletal systems, pregnancy termination and
stillbirth.
Reproductive Effects:
see above.
Neurotoxicity:
No data available.
Mutagenicity:
No data available.
Other Studies:
No data available.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Not available.
Environmental Fate:
Not available.
Physical/Chemical:
Not available.
Other:
Not available.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
RCRA D-Series Maximum Concentration of Contaminants: Not listed.
RCRA D-Series Chronic Toxicity Reference Levels: Not listed.
RCRA F-Series: Not listed.
RCRA P-Series: Not listed.
RCRA U-Series: Not listed.
Not listed as a material banned from land disposal according to RCRA.
**** SECTION 14 - TRANSPORT INFORMATION ****
US DOT
Shipping Name: ALKALOIDS, SOLID, N.O.S.
Hazard Class: 6.1
UN Number: UN1544
Packing Group: III
IMO
No information available.
IATA
No information available.
RID/ADR
No information available.
Canadian TDG
Shipping Name: ALKALOIDS, SOLID,NOS (CAFFEINE)
Hazard Class: 6.1
UN Number: UN1544
**** SECTION 15 - REGULATORY INFORMATION ****
FEDERAL
TSCA
CAS# 58-08-2 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
Section 302 (RQ)
None of the chemicals in this material have an RQ.
Section 302 (TPQ)
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 58-08-2: acute.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous
Substances under the CWA.
None of the chemicals in this product are listed as Priority
Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants
under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous
by OSHA.
STATE
Not present on state lists from CA, PA, MN, MA, FL, or NJ.
California No Significant Risk Level:
None of the chemicals in this product are listed.
INTERNATIONAL
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
Safety Phrases:
Canada
CAS# 58-08-2 is listed on Canada's DSL/NDSL List.
CAS# 58-08-2 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits:
CAS# 58-08-2:. OEL-RUSSIA:STEL 0.5 mg/m3
**** SECTION 16 - ADDITIONAL INFORMATION ****
Additional Information:
No additional information available.
MSDS Creation Date: 4/13/1995 Revision #2 Date: 3/04/1996
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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